Publications where ARUK’s support has been acknowledged

Spatial planning ability in early stage Parkinson’s disease patients
Cristina Nombela, James B Rowe, Sophie Winder-Rodes, Adam Hampshire, Adrian M Owen, David Breen, Tien K Khoo, Michael Firbank, Alison Yarnall, Gordon Duncan,  John T O´Brien, David J Burn, David J Brooks and Roger A Barker (ICICLE-PD).
XVIIth International Congress of Parkinson’s Disease and Movement Disorder)    June 2013

Correcting chromatic offset in multicolor super-resolution localization microscopy
Erdelyi M, Rees EJ, Metcalf D, Kaminski-Schierle GS, Dudas L, Sinko J, Knight AE, Kaminski CF
Optics Express 21 (9), 10978–10988 (2013) DOI: 10.1364/OE.21.010978

‘MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3’
Gooding C, Edge C, Lorenz M, Coelho MB, Winters M, Kaminski CF, Cherny D, Eperon IC, Smith CWJ,
Nucleic Acids Research (2013); doi: 10.1093/nar/gkt168

A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence
Pinotsi D, Buell AK, Dobson CM, Kaminski Schierle GS and Kaminski CF.
ChemBioChem (2013), 14 (7), 846-850, DOI: 10.1002/cbic.201300103.

Lifetime imaging of a fluorescent protein sensor tracks ER thiol redox revealing its surprising stability
Avezov E, Cross BCS, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, Ron D.
JCB (2013), 201 (2), 337-349, doi: 10.1083/jcb.201211155.

Protein amyloids develop an intrinsic fluorescence signature during aggregation
Chan FTS, Kaminski Schierle GS, Kumita JR, Bertoncini CW, Dobson CM and Kaminski CF
Analyst (2013) 138 (7), 2156-2162, DOI: 10.1039/C3AN36798C.

Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of  τ-pathology
Patrick J. Riss,   Laurent Brichard,   Valentina Ferrari,   David J. Williamson,   Tim D. Fryer,   Young T. Hong,   Jean-Claude Baron and Franklin I. Aigbirhio
Med. Chem. Commun., 2013,4, 852-855. DOI: 10.1039/C3MD00017F. (2013)

VBM with viscous fluid registration of grey matter segments in SPM.
João M. S. Pereira, Julio Acosta-Cabronero, George Pengas, Li Xiong, Peter J. Nestor and Guy B. Williams. Frontiers in Aging Neuroscience. 5:30. doi:10.3389/fnagi.2013.00030. (2013)

Diffusion Tensor Metrics as Biomarkers in Alzheimer’s Disease.
Julio Acosta-Cabronero, Stephanie Alley, Guy B. Williams, George Pengas, Peter J. Nestor. PLOS ONE. 7 (11). (2012).

Combining Intracellular Selection with Protein-fragment Complementation to Derive ABeta Interacting Peptides.
Acerra, N., Kad N.M., and Mason, J.M. Protein Eng Des Sel. 26(7), 463-470 (2013).

Tau Protein Is Required for Amyloid!-Induced Impairment of Hippocampal Long-Term Potentiation
Olivia A. Shipton, Julie R. Leitz,Jenny Dworzak, Christine E. J. Acton, Elizabeth M. Tunbridge, Franziska Denk,Hana N. Dawson, Michael P. Vitek, Richard Wade-Martins,Ole Paulsen, and Mariana Vargas-Caballero
The Journal of Neuroscience, February 2, 2011 • 31(5):1688 –1692

Modelling early responses to neurodegenerative mutations in mice.
Gilley, J., Adalbert, R. and Coleman, M.P.  Biochem Soc Trans 39: 933-8.2011

Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline.Alzheimer’s disease and Semantic Dementia.
Marioni RE, van den Hout A, Valenzuela MJ, Brayne C, Matthews FE; MRC Cognitive Function and Ageing Study. J Alzheimers Dis. 2012

Axonpathology in age-related neurodegenerative disorders.
Adalbert, R., and Coleman, M.P. Neuropath Appl Neurobiol EPub ahead of print.    2012

Blind Assessment of Localisation Microscope Image Resolution
Rees EJ, Erdelyi MJ, Pinotsi D, Knight A, Metcalf D and Kaminski CF
Optical Nanoscopy 1(12):1-10 (2012) DOI: 10.1186/2192-2853-1-12

Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme
Ahn M, De Genst E, Kaminski Schierle GS, Erdelyi M, Kaminski CF, Dobson CM, Kumita JR
PLoS One (2012), PLoS ONE 7(11): e50192. doi:10.1371/journal.pone.0050192

Intra-axonal calcium changes after axotomy in wild-type and WldS axons.
Adalbert, R., Morreale, G., Paizs, M., Conforti, L., Walker, S., Roderick, L., Bootman, M., Siklos, L., and Coleman, M.P.
Neuroscience 225: 44-54.

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Osterloh, J.M., Yang, J., Rooney, T.M., Fox, A.N.,Adalbert, R., Powell, E.H., Sheehan, A.E., Avery, M.A., Hackett, R., Logan,M.A., MacDonald, J.M., Ziegenfuss, J.S., Milde, S., Hou, Y-J., Nathan, C., Ding, A., Brown, R.H. Jr., Conforti, L., Coleman, M.P., Züchner, S., Tessier-Lavigne, M. and Freeman, M.R.   Science Epub ahead of print. 2012

The relationship of topographical memory performance to regional neurodegeneration in Alzheimer’s disease.
Pengas G, Williams GB, Acosta-Cabronero J, Ash TW, Hong YT, Izquierdo-Garcia D, Fryer TD, Hodges JR, Nestor PJ.Front Aging Neurosci. 2012;4:17.2012

Hydrophobicity and conformational change as mechanistic determinants for nonspecific modulators of amyloid β self-assembly
Abelein, B. Bolognesi, C.M. Dobson, A. Gräslund and C. Lendel   Biochemistry, 51, 126-137 (2012)

Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells
E.K. McGuire, M. Motskin, B. Bolognesi, S.D. Bergin, T.P. Knowles, J. Skepper, L.M. Luheshi, D.W. McComb, C.M. Dobson and A.E. Porter   ACS Nano, 6, 4760-4767 (2012)

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide
P. Narayan, A. Orte, R.W. Clarke, B. Bolognesi, S. Hook, K.A. Ganzinger, S. Meehan, M.R. Wilson, C.M. Dobson and D. Klenerman  Nature Struct Mol Biol, 19, 79-83 (2012)

The fly as a model for human disease.  Briefings in Functional Genomics
Chen, K. and Crowther, D.C. Oxford University Press.  In press    2012

Expression in Drosophila of tandem Abeta peptides provides insights into the link between aggregation and neurotoxicity
Speretta E., Jahn T.R., Tartaglia G.G., Favrin G., Barros T.P., Imarisio S., Lomas D.A., Luheshi L.M.*, Crowther D.C.*, Dobson C.M* (*equal)  J Biol Chem. Epub date 2012/03/31

Animal models of amyloidosis in “Amyloid”
Ott, S. & Crowther, D.C.  (Otzen, D., ed.) Wiley. In press.2012

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival
Thackray, A.M., Muhammad, F., Zhang, C., Di, Y., Jahn, T., Landgraf, M., Crowther, D.C., Evers, J.F., & Bujdoso, R. Biochem. J., 444(3), 487-495    2012

Prion-induced toxicity in PrP transgenic Drosophila. Exp. Mol. Pathol
Thackray, A.M., Muhammad, F., Zhang, C., Denyer, M., Spiropoulos, J., Crowther, D.C., & Bujdoso, R.  . 92(2), 194-201.    2012

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism
Murakami T., Yang S.P., Xie L., Kawano T., Fu D., Mukai, A., Bohm, C., Chen, F., Robertson, J., Suzuki, H., Tartaglia, G.G., Vendruscolo, M., Kaminski Schierle, G.S., Chan, F.T., Moloney, A., Crowther, D.C., Kaminski, C.F., Zhen, M. & St George-Hyslop, P. Hum Mol Genet, 21 (1), 1-9.2012

Scepticism in medical research in “Scepticism
Crowther, D.C.(Calne, R. & O’Reilly, W., eds.) Nova Science Publishers. In press.2012

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease
Costa R., Speretta E., Crowther D.C., Cardoso IJ Biol Chem, 286 (48), 41647-41655.2012

Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster
Kumita J.R., Helmfors L., Williams J., Luheshi L.M., Menzer L., Dumoulin M., Lomas D.A., Crowther D.C., Dobson C.M., Brorsson A.C.FASEB J, 26 (1), 192-202.    2012


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